In June of 1985,  Mary Ross gathered-long Orthodox Christians to found a worshiping community. She  was joined in this effort by  Nina Rubanov,  Robin Angelopoulos, and Helen Rosolanka, residents of  Victor Valley.

On October 12, 1985, Fr. Theodore Pulcini served the first divine liturgy for the group at the Hesperia Grange Hall. The church continued to meet at the Grange. It was received into the Diocese of San Francisco and the West of the Orthodox Church of America. At that time the church was served by the Rev. Joseph Fester. Weekly services of the Great Vespers on Saturday evenings and divine  liturgies on Sundays were started.

The church was relocated to the Hesperia Medical Center, where the late Dr. Edmund Moushabek provided two rooms for the exclusive use of the mission. The church was able to set up a chapel, and have space for fellowship and educational activities. Several member of the congregation remodeled the interior of the rooms, built a small Iconostasis, purchased icons, and supplied the mission with other necessary things that go into transforming a room into a sacred space.

Fr. John Schreiber, then Priest-in-Charge of St Anthony Orthodox Church, San Antonio, TX, was assigned as the first resident priest. The present church is located in a building that previously hosted the local post office. By the grace of God, the building was donated to the parish community, and, once again, the congregation joyfully and gratefully put in the necessary time, talent, and treasure, to renovate the  building to create space for  a sacristy, a fellowship hall, kitchen, restrooms, storage space, an educational room, and an office.

Later that year, His Grace, Bishop Tikhon of San Francisco and the West blessed the building. On Mother"s Day and the feast of SS Cyril and Methodius (May 11, 1997, the Rev. John Schreiber passed on after a long bout with cancer. Through Fr. John's sacrifice and patience, and his deep abiding love for Christ, His Church, and those committed to his charge, the mission slowly, grew and became established. The liturgical life was enhanced to include regular midweek services and feast days.

The interior of the church has been further adapted to enhance worship according to the liturgical heritage of the Orthodox Church of America, while also reflecting the multi-ethnic makeup of the mission. 

Three priests have since served the parish as pastors: Father Michael Spainhoward, Father Paul Schellbauch and Father Gabriel Seamore (Sipos).  Father Alexander also served the parish  on a part time basis.

The church has recently been repainted.  The Sanctuary floor has been tiled.  The air conditioners and heaters have been repaired. Since 2022 Fr. Alexader has been serving the parish as rector, and the parish continues to grow.